发明名称 |
Acyclic purine phosphonate nucleotide analogs as antiviral agents, and related synthetic methods |
摘要 |
Acyclic purine phosphonate nucleotide analogs useful to treat herpes viral infections are provided in enantiomerically pure form. These antiviral agents have the structural formula (Ia) or (Ib) <IMAGE> (Ia) <IMAGE> (Ib) and may be in acid, salt or ester form. Such compounds may also be dehydrated to provide antiviral agents in cyclic form. Pharmaceutical compositions are provided containing the antiviral agents, as is a chiral synthesis which may be used to prepare the agents in enantiomerically pure form or as a racemic mixture.
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申请公布号 |
US5532225(A) |
申请公布日期 |
1996.07.02 |
申请号 |
US19920922937 |
申请日期 |
1992.07.31 |
申请人 |
SRI INTERNATIONAL |
发明人 |
REIST, ELMER J.;RUHLAND-FRITSCH, BEATRICE;STURM, PRICILLA A. |
分类号 |
C07F9/6561;C07F9/6571;(IPC1-7):A61K31/675;C07F9/651 |
主分类号 |
C07F9/6561 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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