发明名称 |
A tramadol N-oxide material, enantiomers and compositions thereof, and their use |
摘要 |
<p>This invention relates to a tramadol N-oxide material, enantiomers and compositions thereof and their use. The tramadol N-oxide material and compositions thereof are pharmacologically useful in treating pain, diarrhea and tussive conditions. The tramadol N-oxide is also subject to less side-effects as compared to pure opiate based compositions, such as abuse liability, tolerance, constipation and respiratory depression. Furthermore, the tramadol N-oxide material when administered orally exhibits analgesia for a longer duration than an equi-analgesic amount of tramadol.</p> |
申请公布号 |
GR3019345(T3) |
申请公布日期 |
1996.06.30 |
申请号 |
GR19960400740T |
申请日期 |
1996.03.19 |
申请人 |
MCNEILAB, INC. |
发明人 |
MARYANOFF, CYNTHIA A.;VILLANI, FRANK J.;RAFFA, ROBERT B. |
分类号 |
A61K31/14;A61K31/135;A61P1/12;A61P11/14;A61P25/04;C07C291/04;(IPC1-7):C07C291/04 |
主分类号 |
A61K31/14 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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