| 摘要 |
The present invention relates to a novel DNA-RNA hybrid regular tetrahedron structure or RNA tetrahedron structure which can be used in expression inhibition of a target gene or in drug delivery and, more specifically, to a DNA-RNA hybrid regular tetrahedron structure or RNA tetrahedron structure comprising small interfering RNA (siRNA) or microRNA (miRNA) sequences of a target gene. The present invention provides a functional RNA nanostructure in which siRNA or miRNA is introduced, wherein the structure is delivered into a cell through self-delivery at a high efficiency, and can give rise to RNA interference mechanism to induce apoptosis of a target cell. In addition, the present invention can provide a controllable structure in which a drug is released to the outside by supporting the drug in pores. Also, an RNA nanostructure leading to apoptosis of a target cell can be prepared by using RNA interference with the technology of the present invention as the original technology, whereby the RNA nanostructure is expected to be commercialized as a new drug. |
