Förfarande för framställning av terapeutiskt aktiva bis-(hydroximetyl)cyklobutylpuriner och -pyrimidiner

摘要

Antiviral activity is exhibited by compounds having the formula and its pharmaceutically acceptable salts wherein R1 is wherein R2 is hydrogen, methyl, fluoro, chloro, bromo, iodo, hydroxy or amino; R3 is fluoro, chloro, bromo, iodo, hydrogen, methyl, trifluoromethyl, ethyl, n-propyl, 2-fluoroethyl, 2-chloroethyl, or wherein R4 is chloro, bromo, iodo, hydrogen methyl or trifluoromethyl; R5 is alkyl; R6 is hydrogen, alkyl, substituted alkyl, or aryl; and R7 and R8 are independently hydrogen, -PO3H2 or - @-R6.