TACHYKININ ANTAGONISTS

摘要

Compounds of formula (I), wherein R1 is mono- or di-substituted phenyl, n is zero or 1, X1 is oxygen, sulfur or =NCN, X2 and X3 are oxygen or sulfur, R2 is hydrogen or methyl, R3 is phenyl, halo-substituted phenyl, 2-naphthyl, IH-indol-3-yl or 1-methyl-indol-3-yl, Z is -N(CH3)- or -CH2-, R4 is phenyl, 3,5-bis(trifluoromethyl)phenyl or pyridyl and R5 is hydrogen, phenyl 3,5-bis(trifluoromethyl)phenyl or pyridyl, whereby, when X3 is sulfur, Z is -N(CH3)- and acid addition salt thereof have tachykinin antagonist activity and are useful as pharmaceuticals, e.g. for the treatment of pain.