HEXAPEPTIDES POSSESSING ANTITUMOR ACTIVITY

摘要

The present invention provides hexapeptides of the formula (1): X<1>-Y<1>-Y<2>-Y<3>-Tyr-Pro-Trp-X<2> in which X<1> is H, Form, Ac or any amino acid, or an acid addition salt or complex thereof; X<2> is H, any salt, amide, substituted amide or any amino acid; Y<1> is Leu, Ile, Val, Nle, Nva, Ala, Gly; Y<2> is Leu, Ile, Val, Nva, Ala; and Y<3> is Leu, Ile, Val, Nva, Ala. The hexapeptides possess antitumor activity.