发明名称 |
Transferrin receptor specific antibody-neuropharmaceutical agent conjugates |
摘要 |
The present invention pertains to a method for delivering a neuropharmaceutical or diagnostic agent across the blood brain barrier to the brain of a host. The method comprises administering to the host a therapeutically effective amount of an antibody-neuropharmaceutical or diagnostic agent conjugate wherein the antibody is reactive with a transferrin receptor. Other aspects of this invention include a delivery system comprising an antibody reactive with a transferrin receptor linked to a neuropharmaceutical or diagnostic agent and methods for treating hosts afflicted with a disease associated with a neurological disorder.
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申请公布号 |
US5527527(A) |
申请公布日期 |
1996.06.18 |
申请号 |
US19930004986 |
申请日期 |
1993.01.15 |
申请人 |
ALKERMES, INC. |
发明人 |
FRIDEN, PHILLIP M. |
分类号 |
A61K38/00;A61K47/48;A61K51/10;C07K14/475;C07K14/48;C07K14/79;C12N9/08;(IPC1-7):A61K39/44;C07K16/46;C07K17/02 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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