摘要 |
The present invention discloses a photo-induced DNA-cleaving agent composition comprises N-aryl-N-(alkyl or arylalkyl)hydroxylamine having the following formula: <IMAGE> (I) wherein R is C1-C6 alkyl, phenyl, C1-C6 alkoxy, phenoxy, C1-C6 alkoxycarbonyl, halogen or halo(C1-C6 alkyl)wherein R1 is hydrogen, C1-C6 alkyl, phenyl, C1-C6 alkoxy, C1-C6 alkoxycarbonyl, halogen or halo(C1-C6 alkyl); R2 is hydrogen; R3 is hydrogen or phenyl; R4 is hydrogen, phenyl, hydroxylphenyl, methoxyphenyl, dimethoxyphenyl, dimethylaminophenyl or naphthyl. The present N-aryl-N-(alkyl or arylalkyl)hydroxylamine is stable in dark, but it can react with O2 to form HO. radicals under irradiation of UV light for a period of 2-3 hours. The HO. radicals then react with DNA to accomplish cleavage of DNA.
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申请人 |
NATIONAL SCIENCE COUNCIL |
发明人 |
HWU, JIH R.;TSAY, SHWU-CHEN;CHEN, BUH-LUEN;PATEL, HIMATKUMAR V.;CHEN, WAN-LIN;LIN, CHUN C.;CHOU, CHING-TAI |