Phosphonic diester derivatives

摘要

PCT No. PCT/JP94/01307 Sec. 371 Date Apr. 19, 1995 Sec. 102(e) Date Apr. 19, 1995 PCT Filed Aug. 8, 1994 PCT Pub. No. WO95/06051 PCT Pub. Date Mar. 2, 1995.The present invention provides a phosphonic diester derivative of the formula: <IMAGE> wherein R1, R2 and R3 are the same or different and they each represent a hydrogen atom, a lower alkyl group, a halogen atom, a cyano group, a hydroxyl group, or a lower alkoxy group optionally having a halogen atom, a phenyl group or a hydroxypiperidino group as a substituent; R4 represents a hydrogen atom, a lower alkoxy group, a halogen atom, or a lower alkyl group optionally having a halogen atom or a cyano group as a substituent; and R5 and R6 are the same or different and they each represent a hydrogen atom or a lower alkyl group. The derivative of the present invention has excellent hypolipidemic, vasodepressor and hypoglycemic activities and is useful as therapeutic and preventive agents for hyperlipidemic diseases, hypertension and diabetes.