发明名称 |
Vaccines comprising attenuated salmonella having mutations in the ompr genes |
摘要 |
The present invention discloses a novel approach to attenuating bacteria and for their use as live vaccines. The vaccines can be used in human and animal medicine. In particular, there is disclosed a method of attenuating a bacteria by mutating a gene concerned with the regulation of one or more genes concerned with expression of outer membrane proteins, particularly porin proteins.
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申请公布号 |
US5527529(A) |
申请公布日期 |
1996.06.18 |
申请号 |
US19950419741 |
申请日期 |
1995.04.10 |
申请人 |
THE WELLCOME FOUNDATION LIMITED;THE ROYAL SOCIETY;THE LISTER INSTITUTE OF PREVENTIVE MEDICINE;THE UNIVERSITY COURT OF THE UNIVERSITY OF DUNDEE |
发明人 |
DOUGAN, GORDAN;CHATFIELD, STEVEN N.;HIGGINS, CHRISTOPHER F.;DORMAN, CHARLES J. |
分类号 |
C12N15/09;A61K39/02;A61K39/095;A61K39/10;A61K39/102;A61K39/106;A61K39/108;A61K39/112;C12N1/21;C12N15/31;C12R1/01;C12R1/185;C12R1/21;C12R1/42;C12R1/63;(IPC1-7):A61K39/112;C12N15/74 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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