发明名称 |
A novel diagnostic method utilizing ECP, and reagents to be used in the methods |
摘要 |
Diagnostic methods comprise measuring specifically the level of at least one iso-eosinophilic cationic protein (iso-ECP) in a sample from an individual to be diagnosed, and comparing the measured level of the iso-ECP with a predetermined level of the iso-ECP. The iso-ECP is cytotoxic and the cytotoxicity of the iso-ECP is not capable of neutralization by the monoclonal antibodies EG1 and EG2. Anti-iso-ECP antibody which may be used in the diagnostic methods specifically binds to a cytotoxic isoform of ECP having an epitope which is unique for the native form of the cytotoxic iso-ECP. |
申请公布号 |
SE9602234(D0) |
申请公布日期 |
1996.06.06 |
申请号 |
SE19960002234 |
申请日期 |
1996.06.06 |
申请人 |
PHARMACIA AB |
发明人 |
PER VENGE;CHRISTER PETERSON |
分类号 |
G01N33/53;C07K16/18;C07K16/24;C12N5/10;C12N15/02;C12N15/09;C12P21/08;G01N33/68;(IPC1-7):G01N/ |
主分类号 |
G01N33/53 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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