| 摘要 |
PURPOSE: To obtain an amidinophenol derivative useful for preventing and treating inflammatory and allergic diseases, disseminated intravascular coagulation, pancreatitis, multiple organ disorder, etc. CONSTITUTION: Thus compound of formula I [ring D is formula II, III (R<0> is H, a 1-4C alkyl or a 1-4C alkoxy), etc.; T is NH or O; E is a single bond or formula IV (R<300> and R<400> are each H or a 1-4C alkyl); A0 is a single bond, a 1-4C alkylene, an oxy- or a thio-1-4C alkylene or a substitutive 2-8C alkenylene; R is formula V to VII (R<50> and R<60> are each H, a 1-8C alkyl, a 2-8C alkenyl, phenyl, a 1-4C alkylene-O-benzoyl, etc.; R<80> and R<90> are each an alkyl, a 1-4C alkylene-phenyl), etc.], e.g. N-2-propenyl-N- ethoxycarbonylmethyl-4-(4-amidinophenoxycarbonyl)phenoxyacetamide. The leukotriene B4 (LTB4 ) antagonistic agent, phospholipase A2 (PLA2 ) and/or trypsin inhibitor contain the compound of formula I or VIII [R<1> and R<2> are each H or COR<4> (R<4> is a 1-3C alkyl); A is a single bond, a 1-4C alkylene, etc.; R<3> is CON(R<7> )R<8> (R<7> and R<8> are each H, phenyl, etc.)]. |
