| 摘要 |
<p>PURPOSE: To obtain a new N-substituted isoindole-1,3-dione derivative, having excellent inhibiting actions on blood platelet agglutination, useful as an inhibitor of the blond agglutination and expected of use as a preventing and treating agent for diseases caused by the blood platelet agglutination, especially thrombosis such as cardiac or cerebral infarction. CONSTITUTION: This compound of formula I [A and Rare each a lower alkyl; Q is a heterocyclic group, carboxyl, a substituted phenyl, a cyclic amino, a di-substituted lower alkyl or a cycloalkyl; (n) is 0-4], e.g. N-(2-pyridyl)methyl-4,6- dimethyl-5-ethoxycarbonyl-1H-isoindole-1,3-dione. The compound of formula I is obtained by reacting a compound of formula II with a compound of the formula H2 N-(CH2 )n -Q in or without an inert solvent such as dry DMF at 50-200 deg.C, especially 100-150 deg.C temperature, as necessary, in the coexistence of a desiccant such as molecular sieve.</p> |
