发明名称 Modified hepatocytes and uses therefor
摘要 PCT No. PCT/US91/09700 Sec. 371 Date Oct. 22, 1992 Sec. 102(e) Date Oct. 22, 1992 PCT Filed Dec. 23, 1991 PCT Pub. No. WO92/12242 PCT Pub. Date Jul. 23, 1992.Genetically engineered or transduced hepatocytes which express genetic material of interest introduced or incorporated into them, as well as methods of producing, transplanting and using the genetically engineered hepatocytes are disclosed. The genetic material of interest can be incorporated through the use of a vector, such as a recombinant retrovirus, which contains the genetic material of interest, or by other means.
申请公布号 US5521076(A) 申请公布日期 1996.05.28
申请号 US19920938260 申请日期 1992.10.22
申请人 WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH;HOWARD HUGHES MEDICAL CENTER 发明人 MULLIGAN, RICHARD C.;WILSON, JAMES M.
分类号 C12N15/09;A61K38/17;A61K38/29;A61K48/00;C07K14/635;C07K14/705;C12N5/10;C12N15/867;(IPC1-7):C12N15/00;C12N5/00 主分类号 C12N15/09
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