USE OF WORTMANNIN AND ITS ANALOGS FOR PREPARING PREPARATION FOR INHIBITION OF PHOSPHATIDYLINOSITOL-3 KINASE IN MAMMALIAN AND FOR PREPARING PREPARATION FOR TREATMENT OF PHOSPHATIDYLINOSITOL-3 KINASE-DEPENDENT STATES

摘要

FIELD: biochemistry, medicine. SUBSTANCE: wortmannin and its analogs are inhibitors of phosphatidylinositol-3 kinase activity. These compounds are used, in part, for inhibition of phosphatidylinositol-3 kinase activity in mammalian and for treatment phosphatidylinositol-3 kinase-dependent states, in part, neoplasma, in mammalian. EFFECT: increased effectiveness of treatment.