THE TAGA GENE AND METHODS FOR DETECTING PREDISPOSITION TO PEPTIC ULCERATION AND GASTRIC CARCINOMA
摘要
The present invention provides an isolated nucleic acid encoding an approximately 120-128 kilodalton antigen of Helicobacter pylori, or an antigenic fragment thereof, wherein the antigen is associated with peptic ulceration. The present invention also provides methods of detecting the presence of a Helicobacter pylori strain possessing the 120-128 kilodalton antigen in a subject, comprising the steps of contacting an antibody-containing sample from the subject with a detectable amount of the tagA antigen or antigenic polypeptide of the present invention and detecting the binding of the antigen or fragment and the antibody. The detection of a strain expressing the TagA antigen is an indication of predisposition to peptic ulceration and gastric carcinoma. A mutant H. pylori not expressing a functional TagA antigen is also provided.
申请公布号
WO9610639(A3)
申请公布日期
1996.05.17
申请号
WO1995US12669
申请日期
1995.09.29
申请人
VANDERBILT UNIVERSITY;ORAVAX, INCORPORATED;COVER, TIMOTHY, L.;BLASER, MARTIN, J.;KLEANTHOUS, HARRY;TUMMURU, MURALI, K., R.
发明人
COVER, TIMOTHY, L.;BLASER, MARTIN, J.;KLEANTHOUS, HARRY;TUMMURU, MURALI, K., R.