Process for preparing 2-fluoro-cyclopropylamine as well as novel cyclopropylamine derivatives

摘要

Prodn. of 2-fluoro-cyclopropylamine (FCPA) comprises: (i) reaction of a N-vinyl cpd of formula (I) with a carbene of type FXC: to give a cyclopropylamine deriv. (II); and (ii) cleavage of the COY gp and the opt substd benzyl gp from the N atom; R<1>-R<3> = H, halo or 1-6C alkyl, alkoxy or haloalkyl; R<4> = H, 1-6C alkyl or 6-12C aryl; Y = open-chain or cyclic 1-12C alkyl or alkoxy, 6-12C aryl or 7-12C aralkyl or aralkoxy; X = Cl or Br.