Rabbit G protein coupled receptor

摘要

Rabbit gastropyrolic part smooth muscle-derived G protein coupled receptor proteins, partial peptides thereof; and DNAs containing said protein or partial peptide-encoding DNA are provided. The receptor protein and the DNA coding for said protein can be used for 1<FLAC POS=MID> &cir& determination of ligands; 2<FLAC POS=MID> &cir& acquisition of antibody and antiserum; 3<FLAC POS=MID> &cir& construction of expression system for of a recombinant type receptor protein; 4<FLAC POS=MID> &cir& development of the receptor binding assay system using said expression system and screening of the candidate compounds for pharmaceuticals; 5<FLAC POS=MID> &cir& conducting a drug design based upon a comparison with structurally analogous ligands and receptors; 6<FLAC POS=MID> &cir& preparation of probes and PCR primers for a gene diagnosis; 7<FLAC POS=MID> &cir& preparation of transgenic animals; and 8<FLAC POS=MID> &cir& preparation of model patient animals deficient in the receptor protein DNA. Elucidation of the structure and property of the G protein coupled receptor is particularly related to the development of unique pharmaceuticals which act on such a system.