发明名称 |
Human D4 dopamine receptor and its uses |
摘要 |
The present invention is directed toward the isolation, characterization and pharmacological use of the human D4 dopamine receptor. The nucleotide sequence of the gene corresponding to this receptor and alleleic variants thereof are provided by the invention. The invention particularly provides recombinant eukaryotic expression constructs capable of expressing the human D4 dopamine receptor at useful levels in cultures of transformed eukaryotic cells. The invention provides cultures of transformed eukaryotic cells which synthesize such useful amounts of human D4 dopamine receptor protein, and methods for characterizing novel psychotropic compounds using such cultures.
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申请公布号 |
US5516683(A) |
申请公布日期 |
1996.05.14 |
申请号 |
US19930056051 |
申请日期 |
1993.04.29 |
申请人 |
STATE OF OREGON, ACTING BY AND THROUGH THE OREGON STATE BOARD OF HIGHER EDUCATION ON BEHALF OF THE OREGON HEALTH SCIENCES UNIVERSITY A NON-PROFIT ORGANIZATION |
发明人 |
GRANDY, DAVID K.;BUNZOW, JAMES R.;CIVELLI, OLIVIER;VAN TOL, HUBERT H.-M. |
分类号 |
C07K14/705;C12Q1/68;G01N33/94;(IPC1-7):C07K14/705;C12N15/12 |
主分类号 |
C07K14/705 |
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