发明名称 |
Preparation of C-13 hydroxyl-bearing taxanes using nocardioides or a hydrolase isolated therefrom |
摘要 |
Compounds useful as intermediates in the preparation of taxanes such as taxol are prepared by contacting one or more C-13 acyloxy-bearing taxanes with an enzyme or microorganism capable of hydrolyzing said acyloxy groups to hydroxyl groups. In a preferred embodiment the microorganism is Nocardioides albus ATCC55424, Nocardioides albus ATCC55425 or Nocardioides luteus ATCC55426 or the hydrolase enzyme is isolated from the microorganisms.
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申请公布号 |
US5516676(A) |
申请公布日期 |
1996.05.14 |
申请号 |
US19930077979 |
申请日期 |
1993.06.15 |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
HANSON, RONALD L.;PATEL, RAMESH N.;SZARKA, LASZLO J. |
分类号 |
C07D305/14;C12N9/18;C12P17/02;C12Q1/04;(IPC1-7):C12P17/02;C12N9/14 |
主分类号 |
C07D305/14 |
代理机构 |
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主权项 |
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地址 |
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