| 摘要 |
PURPOSE: To obtain the subject compound, represented by a specific formula, hardly undergoing the hydrolysis with an enzyme in the living body, readily synthesized, suitable for anti-sense molecules and useful as medicines capable of inhibiting the function of a gene and treating diseases such as an antitumor agent. CONSTITUTION: This compound is expressed by formula I [B1 is pyrimidine, a purine nucleic aid base or its derivative; X and Y are each O or S; R is H, an alkyl or an acyl; W is H, an alkyl or an acyl or may be a (oligo) nucleotide or a polynucleotide through a phosphoric ester bond when X is O; (n) is 1-50]. Furthermore, the compound is preferably obtained by selecting, e.g. an optically active (S)-glycidol of formula II as a raw material, initially reacting the selected optically active (S)-glycidol with aqueous ammonia, subsequently adding triethylamine and di-t-butyl carbonate thereto, stirring the prepared mixture, further adding and reacting t-butyldiphenylsilyl chloride and 4-dimehylaminopyridine with the mixture and passing the reactional product through the resultant monomer unit intermediate, etc. |
