发明名称 |
CHIMERIC RECEPTORS FOR THE GENERATION OF SELECTIVELY-ACTIVATABLE TH-INDEPENDENT CYTOTOXIC T CELLS |
摘要 |
The invention provides cytotoxic T lymphocytes that express a chimeric cell surface receptor. The chimeric receptor enables the lymphocytes to become activated and to proliferate (via a TH-independent autocrine cycle) in response to adhesion between the lymphocyte and an antigen displaying cell (ADC) that might not normally activate the T cell. The chimeric receptors of the present invention comprise fusion polypeptides of the following structure: XC-TM-IC28, wherein (XC) is an extracellular region derived from a receptor for a ligand that is expressed on the surface of an antigen-displaying cell, fused via a transmembrane region (TM) to an intracellular region (IC28) which is derived from the intracellular region of the CD28 receptor.
|
申请公布号 |
CA2204183(A1) |
申请公布日期 |
1996.05.09 |
申请号 |
CA19952204183 |
申请日期 |
1995.11.01 |
申请人 |
TARGETED GENETICS CORPORATION |
发明人 |
JONES, LORI ANN;FELDHAUS, ANDREW LAWRENCE |
分类号 |
A61K38/00;C07K14/705;C12N5/0783;C12N15/12;(IPC1-7):C12N15/12;C12N5/10;A61K35/14;C12N15/62;C07K14/725 |
主分类号 |
A61K38/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|