TAXOID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS ANTITUMOR AGENTS

摘要

This invention relates to a taxoid of formula (I), wherein R<1> is a C3-C5 alkyl or alkenyl radical; R<2> is a C3-C5 branched alkyl radical; R<3> and R<4> are independently selected from hydrogen and hydroxyl protecting groups including functional groups which increase the water solubility of the taxoid antitumor agent; R<5> is a hydrogen, an acyl radical, or an alkoxylcarbonyl or carbamoyl radical; and R<6> is an acyl radical. The compounds of formula (I) are useful as antitumor agents or their precursors. This invention also relates to a pharmaceutical composition having antineoplastic activity comprising the compound of formula (I) and a physiologically acceptable carrier and method of treatment using the compound of formula (I).