发明名称 |
PROCESSES AND INTERMEDIATES FOR PREPARING 5,7-DIHYDRO-3-[2-{1-BENZYLPIPERIDIN-4-YL}ETHYL]-6H-PYRROLO-[4,5-f]-1,2-BENZISOXAZOL-6-ONE |
摘要 |
This invention relates to a process for preparing the compound having formula (I) which comprises i) heating the compound of formula (VII) wherein R<3> is R<4> or benzyl and R<4> is R<5>C(=O), R<5>OC(=O) or R<5>SO2 wherein R<5> is (C1-C6)alkyl or (C6-C10)aryl(C1-C6)alkyl; at an elevated temperature in the presence of a base with the proviso that when R<3> in the resultant product is R<4> said product is ii) further treated with an aqueous mineral acid at an elevated temperature followed by iii) treatment of the product of ii) with a) a benzylating agent in the presence of a base or b) benzaldehyde in the presence of a reducing agent and an acid.
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申请公布号 |
WO9613505(A1) |
申请公布日期 |
1996.05.09 |
申请号 |
WO1995IB00755 |
申请日期 |
1995.09.13 |
申请人 |
PFIZER INC.;DEVRIES, KEITH, M.;VILLALOBOS, ANABELLA |
发明人 |
DEVRIES, KEITH, M.;VILLALOBOS, ANABELLA |
分类号 |
C07D401/06;C07D498/04;(IPC1-7):C07D498/04;A61K31/42 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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