Bridged and unbridged quadruplex/duplex oligonucleotides

摘要

A single stranded oligodeoxyribonucleotide that binds to thrombin upon contact comprising a quadruplex consensus motif flanked by complementary sequences which form a duplex-stem motif. A single stranded oligodeoxyribonucleotide that binds to thrombin upon contact comprising a quadruplex consensus motif whose 5' and 3' termini are connected by a bridging moiety. Methods of inhibiting and detecting thrombin using one or more of such oligodeoxyribonucleotides are presented.