PHARMACEUTICALLY ACTIVE SUBSTITUTED AROMATIC COMPOUNDS

摘要

The present invention relates to compounds of formula (I), wherein: A, B and D are various ring systems as defined in the description, R<1> is one of a variety of groups as defined in the description, R<3> is hydrogen or C1-4 alkyl and Z is of the formula -(CH(R<5>))m-, -(CHR<5>)pCR<5>=CR<5>(CHR<5>)q-, -(CHR<5>)rC(=O)CR<5>(CHR<5>)s- or -(CHR<5>t)C(=O) (CHR<5>)u-, wherein m is 2, 3 or 4, p and q are independently 0, 1 or 2 providing p+q is not greater than 2, one of r and s is 0 and the other is 1 and t and u are independently 0, 1, 2 or 3 providing t + u is not less than 1 or greater than 3; and R<5> is hydrogen, methyl, ethyl, hydroxy, methoxy or ethoxy; and N-oxides where chemically possible; and S-oxides where chemically possible; and pharmaceutically acceptable salt and in vivo hydrolysable ester amide thereof. Processes for their preparation, their use as therapeutic agents and pharmaceutical compositions containing them.