BIS-2-AMINOPYRIDINES, PREPARATION METHOD THEREFOR AND USE THEREOF FOR CONTROLLING PARASITIC INFECTIONS

摘要

Substituted bis-2-aminopyridines of general formula (I), wherein Q is a C6-20 alkyl grouping, an optionally substituted aryl grouping, or a cycloalkyl grouping, and forms, between the two pyridine rings, a hydrocarbon chain including 6-34 carbon atoms in all; n is a number from 0 to 7; and R1, R2, R3 and R4, which are the same or different, are a hydrogen atom, a straight or branched optionally substituted C1-6 alkyl grouping, an aryl grouping optionally substituted by one or more halogen atoms, or C1-6 alkyl or C1-6 alkoxy radicals, a benzyl grouping, a thienyl grouping, a furyl grouping, a halogen atom or an alkoxy or benzyloxy grouping, with the proviso that at least one of radicals R1, R2, R3 and R4 is not a hydrogen atom when Q is a (CH2)m chain wherein m is 6-20; and addition salts thereof. A method for preparing said substituted or unsubstituted bis-2-aminopyridines, and the use thereof as a drug and in particular as active drugs for controlling parasitic infections within red blood cells, e.g. malaria or babesiasis (or piroplasmosis), are also disclosed.