发明名称 |
Vascular hypertrophy suppression treatment |
摘要 |
This invention relates to a method for the prophylaxis or treatment of vascular hypertropy in a mammal by administering a pharmaceutically effective amount of a compound represented by the formula (I): <IMAGE> wherein ring W is a nitrogen-containing heterocyclic ring residue which may be substituted; R1 is hydrogen or an optionally substituted hydrocarbon residue which optionally binds through a hetero-atom; R3 represents a group capable of forming an anion or a group capable of changing thereto; X shows that the phenylene and phenyl groups bind to each other directly or through a spacer having an atomic length of two or less; n denotes 1 or 2; a and b forming the heterocyclic ring residue are independently one or two optionally substituted carbon or hetero atoms; c is an optionally substituted carbon or hetero atom; provided that, when the ring W is a condensed ring, R1 is hydrogen or an optionally substituted hydrocarbon residue which binds through a hetero atom, or a salt thereof to a mammal in need thereof.
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申请公布号 |
US5508297(A) |
申请公布日期 |
1996.04.16 |
申请号 |
US19940201122 |
申请日期 |
1994.02.24 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
NISHIKAWA, KOHEI |
分类号 |
A61K31/415;A61K31/4184;A61K31/422;A61P9/10;(IPC1-7):A61K31/41 |
主分类号 |
A61K31/415 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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