| 摘要 |
This invention relates to antimicrobial compounds of formula I, II, or III <IMAGE> I <IMAGE> II <IMAGE> III wherein R1 and R2 are independently selected from hydrogen, halogen, or (C1-C4)alkyl; R1 and R2 may be taken together with the carbons to which they are attached to form a 5 to 7-membered carbocyclic ring and the ring may be aromatic; R3 is hydrogen, (C1-C8)alkyl, (C2-C8)alkenyl, (C5-C8)alkynyl, (C5-C7)cycloalkyl or cycloalkenyl, phenyl or substituted phenyl, (C7-C10)aralkyl or substituted (C7-C10)aralkyl, or a 5 to 8-membered heteroaryl having one or more heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen; R4 is an electron-withdrawing group selected from CN, NO2, P(O)(OR7)2, P(S)(OR7)2, COOR6, COR6, CONHR6, SOR6, SO2R6, where R6 is hydrogen, (C1-C8)alkyl, phenyl or substituted phenyl, (C7-C10)aralkyl or substituted (C7-C10)aralkyl, (C5-C7)cycloalkyl, or a 5 to 8-membered heteroaryl having one or more heteroatoms selected from the group consisting of oxygen, sulfur and nitrogen and where R7 is (C1-C4)alkyl or phenyl; R3 and R4 may be joined to form a (C5-C7)cycloalkenone optionally containing a heteroatom selected from the group consisting of oxygen, sulfur and nitrogen; R5 is hydrogen or (C1 to C4)alkyl; and Y is oxygen, sulfur, sulfoxide, sulfone, or nitrogen substituted with (C1-C4)alkyl, (C3-C5)cycloalkyl, or phenyl.
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