FARNESYLTRANSFERASE INHIBITOR.

摘要

A farnesyltransferase inhibitor and an antitumor drug each containing a piperazinedione derivative represented by general formula (I) as the active ingredient, wherein R<1> and R<2> are the same or different from each other and each represents lower alkyl, lower alkoxyalkyl, or (un)substituted aryl or aralkyl; R<3> and R<4> are the same or different from each other and each represents mercapto, lower alkanoylthio, aroylthio, lower alkoxycarbonylthio or aryloxycarbonylthio, or R<3> and R<4> are combined with each other to represent a disulfide bond; and R<5> and R<6> are the same or different from each other and each represents hydrogen, lower alkyl, lower alkoxyalkyl, hydroxyalkyl, lower alkanoyloxyalkyl, aroyloxyalkyl, aralkyloxyalkyl or aralkyl.