| 摘要 |
FIELD: organic chemistry. SUBSTANCE: products: derivative of piperazine of the formulawhere Q - aryl-group, heterocyclic-group, diarylmethyl-group, aralkyl-group containing aryl-group and alkylene-group, alkyl-group or cycloalkyl-group in which aryl-group, heterocyclic group and aryl-moiety of diarylmethyl-group and aralkyl-group can be substituted with one or more substituents; R - bicyclic, substituted, nitrogen-containing heterocyclic-group or substituted phenyl-group in which nitrogen-containing heterocyclic group has 5-membered substituted aromatic or unsaturated ring containing one or two nitrogen atoms, and 6-membered ring; Z - alkylene group, alkenylene group, alkylene group, carbonyl group, alkylene group containing carbonyl group or oxalyl-group, or its salt. Compounds inhibit calmodulin activity and can be used in medicine as drugs in hematology, for cerebral disease treatment at excess calmodulin activity. EFFECT: improved method of synthesis. |
