| 摘要 |
PURPOSE: To produce a mandelamide (derivative) useful e.g. as a raw material for pharmaceuticals and agrochemicals in high yield while suppressing the inactivation of enzyme by treating a specific cyanhydrin, etc., with a specific microorganism (or its treated product) under specific condition. CONSTITUTION: This optically active S-(+)-mandelamide (derivative) of formula III is produced by adding an aldehyde of formula II corresponding to a racemic cyanhydrin of formula I (X is H, methyl, methoxy, isopropyl, hydroxyl, nitro, sulfone or a halogen) (e.g. mandelonitrile) to the racemic cyanhydrin or the aldehyde of formula II corresponding to the cyanhydrin and hydrocyanic acid and treating the mixture with a microorganism belonging to the genus Rhodococcus, etc., capable of stereospecifically hydrating the cyan group of the cyanhydrin or its treated product in a neutral or basic aqueous medium. The amount of the aldehyde of formula II to be added to the racemic cyanhydrin is 1-10mol per 1mol of the racemic cyanhydrin and 2-11mol based on 1mol of hydrocyanic acid and within the range to be soluble in the reaction system. |
