PHENYL-OXO-ALKYL-(4-PIPERIDINYL)BENZOATE DERIVATIVES

摘要

The present invention is concerned with novel benzoate derivatives having formula (I), the N-oxide forms, the pharmaceutically acceptable acid addition salts and the stereochemically isomeric forms thereof, wherein R<1> is halo or C1-6alkylsulfonylamino; either R<2> is hydrogen and R<3> is C1-6alkyl, C2-6alkenyl or C2-6alkynyl; or R<2> and R<3> taken together form a bivalent radical of formula -CH=CH- (a), -(CH2)2- (b), or -(CH2)3- (c); in the bivalent radicals of formula (a), (b) or (c) one or two hydrogen atoms may be replaced by C1-6alkyl; Alk is C1-6alkanediyl; R<4> is hydrogen or C1-6alkyloxy; R<5>, R<6> and R<7> each independently are hydrogen, halo, C1-6alkyl, C1-6alkyloxy; or R<5> and R<6> taken together may also form a bivalent radical of formula: -NR<8>C(O)NR<9>-, -NH-C(NHR<10>)=N-, -O-(CH2)m-O-; R<8> and R<9> each independently are hydrogen or C1-6alkyl; R<10> is hydrogen, C1-6alkycarbonyl, C1-6alkyloxycarbonyl; m is 1 or 2. Pharmaceutical compositions comprising said compounds, processes for preparing compounds and compositions as well as the use as a medicine, in particular for the treatment of intestinal disorders involving a decreased colon motility are described.