| 发明名称 |
CYCLIC PEPTOLIDES |
| 摘要 |
Cyclic peptolides having the structure of a cyclosporin in which one amide linkage is replaced by an ester linkage are obtained by fermentation of fungal strains of the genus Cylindrotrichum Bonorden, or by cyclisation of a hydroxy-undecapeptide. The cyclic peptolides have immunosuppressive, anti-inflammatory and anti-parasitic properties. |
| 申请公布号 |
CA1338183(C) |
申请公布日期 |
1996.03.26 |
| 申请号 |
CA19880569655 |
申请日期 |
1988.06.16 |
| 申请人 |
SANDOZ LTD. |
发明人 |
DREYFUSS, MICHAEL MORRIS;SCHREIER, MAX H.;TSCHERTER, HANS;WENGER, ROLAND |
| 分类号 |
A61K;A61K38/00;A61P29/00;A61P37/06;C07K;C07K1/02;C07K1/113;C07K11/02;C07K14/37;C07K14/41;C12N;C12N1/14;C12P;C12P21/04;C12R;C12R1/645 |
主分类号 |
A61K |
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