SYNTHETIC GANGLIOSIDE DERIVATIVES

摘要

Compositions of matter comprising glycosphingolipids useful for suppressing an immune response having formula (I) wherein x is (a) or (b) or H; wherein Y is (c) or H; wherein m is 10 to 20; and wherein n is 1 to 14. Also presented are methods for suppressing an immune response in an animal employing glycosphingolipids as shown above. Synthetic gangliosides having artificial hydrophobic anchors, useful for suppressing an immune response having formula (II) wherein A is a carbohydrate moiety of a ganglioside, n is 5 to 20 and m is 5 to 20. Also presented are methods for suppressing an immune response in an animal and compositions of matter employing synthetic gangliosides having artificial hydrophobic anchors, as shown above. Simplified carbohydrate moiety-gangliosides, useful for suppressing an immune response according to formula (III) wherein B is a ceramide moiety of a ganglioside. Also presented are methods for suppressing an immune response in an animal and compositions of matter employing simplified carbohydrate moiety-ganglioside as shown above.