发明名称 |
Thermostable ribonuclease H and genetic constructs therefore |
摘要 |
An essentially pure preparation of thermostable RNase H isolated from Thermus flavus is disclosed. In one preferable form of the invention, the RNase H is capable of biological activity after incubation at temperatures equal to or greater than 70 DEG C. for at least ten minutes. The present invention is also a method of digesting RNA polymers that are in duplex form with a DNA molecule. The method comprises exposing the duplex to the isolated thermostable RNase H. The present invention is also a genetic construct capable of expressing a thermostable RNase H.
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申请公布号 |
US5500370(A) |
申请公布日期 |
1996.03.19 |
申请号 |
US19950465161 |
申请日期 |
1995.06.05 |
申请人 |
EPICENTRE TECHNOLOGIES |
发明人 |
JENDRISAK, JEROME J.;SMITH, ROBERT E.;DAHL, GARY A. |
分类号 |
C12N9/22;C12N15/55;(IPC1-7):C12N9/22;C12N15/62 |
主分类号 |
C12N9/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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