发明名称 |
NON SELF-INACTIVATING, EXPRESSION TARGETED RETROVIRAL VECTORS |
摘要 |
The present invention relates to a retroviral vector undergoing promoter conversion comprising a 5'LTR region of the structure U3-R-U5; one or more sequences selected from coding and non-coding sequences; and a 3'LTR region comprising a completely or partially deleted U3 region wherein said deleted U3 region is replaced by a polylinker sequence, followed by the R and U5 region. Said retroviral vector undergoes promoter conversion and is useful as a gene transfer vehicle for targeted gene therapy.
|
申请公布号 |
CA2198210(A1) |
申请公布日期 |
1996.03.14 |
申请号 |
CA19952198210 |
申请日期 |
1995.09.01 |
申请人 |
GSF-FORSCHUNGSZENTRUM FUE UMWELT UND GESUNDHEIT GMBH |
发明人 |
GUENZBURG, WALTER HENRY;SALLER, ROBERT MICHAEL |
分类号 |
C12N15/09;A61K35/76;A61K48/00;C12N7/00;C12N15/11;C12N15/86;C12N15/867;(IPC1-7):C12N15/86;C12N7/01;C12N5/10;A61K31/70 |
主分类号 |
C12N15/09 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|