发明名称 |
Stable emulsion suitable for pharmaceutical administration, the production thereof and emulsion for pharmaceutical use |
摘要 |
A stable active substance emulsion of the oil-in-water type with a phospholipid as emulsifier is described, where the active substance dissolved in the lipid phase has one or more basic groups, is hydrophobic and oil-soluble, and has a pKa of at least 7.5, the aqueous phase is set at an acid pH, and the disperse phase gives a positive zeta potential of at least +15, but preferably +30, mV after dilution of the emulsion ready for administration to a fat content of 0.08% by weight.
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申请公布号 |
US5496818(A) |
申请公布日期 |
1996.03.05 |
申请号 |
US19930057553 |
申请日期 |
1993.05.06 |
申请人 |
KNOLL AKTIENGESELLSCHAFT |
发明人 |
SCHAUPP, KARIN;POLZER, JOSEF;KERBL, JOHANNES;LANTHALER, KURT;DAVIS, STANLEY S.;WASHINGTON, CLIVE |
分类号 |
A61K9/107;A61K31/275;B01F17/00;(IPC1-7):A61K31/54 |
主分类号 |
A61K9/107 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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