摘要 |
<p>Method for preparing purified influenzal antigens from a liquid containing the influenzal virus, comprising the steps of concentration, purification, fragmentation and optionally inactivation, characterized in that: A. either the purification step comprises a plurality of ultracentifugation steps separated by a filtration step, B. or the fragmentation step is carried out on the living virus in the presence of a non ionic amphiphilic detergent followed by the removal of undesirable substances by filtration retaining all of the viral constituents, or the method is carried out according to these two steps in any order.</p> |