IMIDAZOLIDINE DERIVATIVE AND USE THEREOF

摘要

An imidazolidine derivative represented by general formula (1) and medicines containing the derivative as the active ingredient, representative examples of which include a chymase inhibitor and a preventive or remedy for cardiac and circulatory diseases caused by abnormal palpitation induced by angiotensin II, wherein A and B represent each an aromatic hydrocarbon group which may be substituted by one to three substituents selected from among halogen, C1-C4 alkyl, C1-C4 alkoxy, C1-C4 alkylenedioxy, phenoxy, nitro, cyano, phenyl, C2-C5 alkanoylamino, carboxyl which may be esterified with C1-C4 alkyl or alkenyl, carboxyalkyl which may be esterified with C1-C4 alkyl or alkenyl, carboxyalkyloxy which may be esterified with C1-C4 alkyl or alkenyl, N-alkylpiperazinylcarbonyl, N-alkylpiperazinylcarbonylalkyl, N-alkyl-piperazinylcarbonylalkyloxy and morpholinocarbonyl; X represents sulfonyl or carbonyl; and Y represents oxygen or sulfur.