发明名称 |
Process for the preparation of clavulanic acid |
摘要 |
<p>A process for the preparation and/or purification of clavulanic acid or a pharmaceutically acceptable salt thereof comprises i) contacting impure clavulanic acid or an alkali metal salt thereof in an organic solvent, with tertiary octylamine; ii) isolating the tertiary-octylamine salt of clavulanic acid formed; iii) converting the thus formed salt into clavulanic acid or a pharmaceutically acceptable salt or ester thereof.</p> |
申请公布号 |
EP0672670(B1) |
申请公布日期 |
1996.02.14 |
申请号 |
EP19950201085 |
申请日期 |
1993.06.07 |
申请人 |
SMITHKLINE BEECHAM PLC |
发明人 |
COOK,MICHAEL,ALLEN;WILKINS, ROBERT BENNETT |
分类号 |
C07D503/06;A61K31/42;A61P31/04;C07B63/02;C07D;C07D498/04;C07D503/00;C07D503/14;C07D503/18;C12P17/18;C12R1/465;(IPC1-7):C07D503/18 |
主分类号 |
C07D503/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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