RETROVIRAL TRANSDUCTION OF CELLS USING SOLUBLE COMPLEMENT INHIBITORS
摘要
Methods and compositions are provided for facilitating gene therapy procedures involving the transduction of target cells with retroviral vector particles in the presence of complement containing body fluids. The administration of soluble complement inhibitor molecules to body fluids prevents the complement mediated inactivation of the retroviral vector particles, and provides a safety mechanism for such gene therapy procedures, as the action of soluble complement inhibitors is transient, and any retroviral vector particles present after the return of uninhibited complement activity will be inactivated.
申请公布号
WO9603146(A1)
申请公布日期
1996.02.08
申请号
WO1995US08924
申请日期
1995.07.14
申请人
ALEXION PHARMACEUTICALS, INC.
发明人
ROTHER, RUSSELL, P.;ROLLINS, SCOTT, A.;MASON, JAMES, M.;SQUINTO, STEPHEN, P.