N-ACYL-N-(SUBSTITUTED CINNAMOYL)ETHYLENEDIAMINE DERIVATIVE

摘要

A novel N-acyl-N-(substituted cinnamoyl)ethylenediamine derivative represented by general formula (I) and serving as an antiphlogistic and/or NGF production accelerator, (wherein R<1> represents the acyl residue of a C16 or higher unsaturated fatty acid; R<2> and R<3> represent each independently hydrogen or lower alkyl; and n represents 1 or 2). This compound is expected to be usable as, for example, an antiphlogistic because it has the activities of O2<-> production inhibitor in human neutrophilic leukocytes and intracellular phospholipase A2 inhibition, and as a remedy for dementia, spinal cord injury, peripheral nerve injury, diabetic neuropathy and amyotrophic lateral sclerosis because it has the activity of accelerating NGF production.