NOVEL HYALURONIDASE

摘要

A novel hyaluronidase (HAase) isolated from a supernatant of a human uterine body cancer tissue culture by means of sodium dodecyl sulfate-polyacrylamide gel electrophoresis using hyaluronic acid, modified chondroitin sulfate or the like as the substrate. The obtained HAase hydrolyzes hyaluronic acid at a pH of 3.5 to 7.5, but not chondroitin sulfate, and is useful for, for example, searching remedies for cerebral edema, myocardial infarct and the like, drug additives, and hyaluronidase inhibitors.