发明名称 |
ANTISENSE OLIGONUCLEOTIDES AGAINST HEPATITIS B VIRAL REPLICATION |
摘要 |
Antisense oligonucleotides that hybridize to segments of the preS1, S, C, and epsilon regions of the hepatitis B virus (HBV) RNA pregenome inhibit replication of the virus. The figure illustrates the relative positions of antisense oligonucleotides targeted against the HBV S gene. Pharmaceutical compositions which contain these oligonucleotides as the active ingredients are effective against HBV infection.
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申请公布号 |
CA2196070(A1) |
申请公布日期 |
1996.02.08 |
申请号 |
CA19952196070 |
申请日期 |
1995.07.28 |
申请人 |
GEORGETOWN UNIVERSITY |
发明人 |
KORBA, BRENT E.;GERIN, JOHN L. |
分类号 |
C12N15/09;A61K31/70;A61K31/7088;A61K38/00;A61K48/00;A61P31/12;C07H21/04;C12N15/113;(IPC1-7):C07H21/04 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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