| 摘要 |
A therapeutic agent for the treatment of xerostomia comprises a derivative of spirooxathiolane-quinuclidine or an acid addition salt thereof as an active ingredient represented by the following formula ÄIÜ: <CHEM> (wherein R<1> and R<2> may be the same or different and each represents hydrogen, alkyl, cyclopentyl, cyclohexyl, aryl, diarylmethylol, or alkyl which may be substituted by one or more aryl groups). The above therapeutic agent can be administered orally or parentally and cure xerostomia. Specifically, the agent can be used for improving and/or curing dry mouth caused by various diseases with organic changes in salivary gland, lesions in salivary gland accompanied with systemic diseases, necrosis of salivary gland cell by radiotherapy, HIV infection (AIDS), hypo-function of saliva secretion, affection of various medicines taken and, further, mental fatigue or bad conditions due to complex social life situations. |
