发明名称 |
LONG-ACTING OXYTETRACYCLINE COMPOSITION |
摘要 |
An injectable composition of higher residual effect with reduced detrimental effects such as pain at injection site, swelling, tissue irritancy or necrosis and containing as active principle a tetracycline compound, either as the free base or a salt thereof with a physiologically acceptable acid, complexed with a substantially equimolar amount of a magnesium compound, is solubilised in a water miscible solvent system comprising, either (i) a) glycerol formal in an amount of from about 10 to about 50 % v/v; with b) polyethylene glycol in an amount of from about 1 to 15 % v/v; or (ii) from about 25 to about 75 % v/v of N-methylpyrrolidone, said composition optionally containing a pH modifier in an amount sufficient to maintain a physiochemically acceptable pH, the balance being made up with water q.s.
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申请公布号 |
WO9601634(A1) |
申请公布日期 |
1996.01.25 |
申请号 |
WO1995GB01583 |
申请日期 |
1995.07.05 |
申请人 |
NORBROOK LABORATORIES LIMITED;PATTERSON, ALAN;HOLMES, DREW |
发明人 |
PATTERSON, ALAN;HOLMES, DREW |
分类号 |
A61K31/65;A61K47/02;A61K47/10;A61K47/22;(IPC1-7):A61K31/65;A61K47/00 |
主分类号 |
A61K31/65 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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