PROCESS FOR PREPARING NEW DERIVATIVES OF 2'-AND/OR 3'-O-NITRO-ADENOSINE-5'-CARBOXYLIC ACID

摘要

1489327 Adenosine nitrates F HOFFMANNLA ROCHE & CO AG 17 Feb 1976 [18 Feb 1975 4 July 1975] 06162/76 Heading C2C Novel compounds I and their acid addition salts in which R1 and R2 are H or NO 2 and at least one is NO 2 , and R5 is OH, C 1-6 alkoxy, amino optionally mono- or di-C 1-6 alkylated, aryl- C 1-6 alkylamino, [2 - (dimethylamino)ethyl]- amino, [2- (2,4 - dinitrophenyl) - ethyl]amino or (2 - nitrooxyethyl)amino, cycloalkylamino or an N-containing heterocyclic ring bonded via an N-atom are prepared by nitrating a compound II Compounds I affect the heart and circulatory dynamics and form with a carrier a pharmaceutical composition which may be administered orally or parenterally.