摘要 |
The present invention provides synthetic peptide derivatives represented by the formula P<1>-R<1>-P<2> wherein P<1> is a peptide having an amino acid sequence in the SEQ ID NO.:1 of the Sequence Listing, or analogues thereof; P<2> is a peptide having an amino acid sequence in the SEQ ID NO.:2 of the Sequence Listing, or analogues thereof; R<1> denotes a linker with a property that does not interfere with the activity of the each peptide P<1> and P<2> to bind N-terminal end of the peptides P<1> and P<2>. The present invention also provides a pharmaceutical composition for the treatment of bone related diseases comprising said peptide derivatives, or a therapeutically acceptable salt thereof, and a pharmaceutically acceptable carrier. The present invention also provides a method of treating bone related diseases in a mammal comprising administering thereto an effective amount of said peptide derivatives, or therapeutically acceptable salts thereof. |