A chromosome integration vector

摘要

A chromosome integration vector for a host fungus containing the aureobasidin resistant gene is disclosed, with a process for producing an aureobasidin resistant transformant which comprises obtaining the vector through the cleavage of a replication vector, integrating the vector into the chromosome of a host fungus and screening the host thus obtained. The vector so obtained may contain a foreign gene. Also disclosed is a protein capable of imparting aureobasidin resistance wherein at least the 240th amino acid residue in the protein represented by SEQ ID No.1 in the Sequence Listing, which is capable of imparting the sensitivity to aureobasidin, has been replaced by another amino acid residue, or another protein capable of imparting aureobasidin resistance which has an amino acid sequence obtained by subjecting the above-mentioned protein to at least one modification selected from replacement, insertion and deletion of amino acid residue(s). A DNA coding for the protein is disclosed.